Methionine for Anxiety and Depression

Methionine is an amino acid that is commonly found in protein foods. Research shows that persons suffering from some forms of anxiety and depression have low methylation. Methylation is an essential process inside the human body where a donor molecule like Methionine gives methyl molecules to other molecules that needs it. The production of neurotransmitters which are responsible for normalizing mood requires the methylation process. A person with low methylation makes fewer serotonin and thus becomes depressed. The action of Methionine is similar to Sam-E because the body can manufacture Sam-E from Methionine. Methionine is several times cheaper than Sam-E, which makes Methionine cost effective when used over long periods of time. Take note that Methionine raises homocysteine levels. Homocysteine is not good for your heart but you can lower the homocysteine levels inside your body by taking Vitamin B6, B12 and Folic acid along with Methionine.



“A number of randomized controlled clinical trials have demonstrated the efficacy of methionine (or s-adenosylmethionine) supplementation in the treatment of major depression” (Kagan et al, 1990; Salmaggi et al, 1993; Bell et al, 1994; Delle Chiaie et al, 2002).

“Clinical trial studies have shown methionine to be a safe, effective antidepressant with a rapid onset of action and few side effects. The efficacy and safety of methionine in depression have been recently reviewed “ (Papakostos et al, 2003; Williams et al, 2005).

Dosage and Sources:

Methionine can be found naturally on foods rich in protein such as meat, fish milk and cheese. It is also sold as a food supplement which is available in 500 mg capsules.



1. Bell KM, Potkin SG, Carreon D et al (1994) S-adenosylmethionine blood levels in major depression: changes with drug development. Acta Neurol Scand; 154: 15-18.
2. Brok J, Buckley N, Gluud C (2002) Interventions for paracetamol overdoses. Cochrane Database Syst Rev CD003328
3. Charlton M (2006) Branched chain amino acid enriched supplements as therapy for disease. J Nutr; 136(S1): 295-298.
4. Delle Chiaie R, Pancheri P, Scapicchio P (2002) Efficacy and tolerability of oral and intramuscular s-adenosylmethionine in the treatment of major depression. Am J Clin Nutr; 76(5): 1172-1176.
5. Janes J, Routledge PA (1992) Recent developments in the management of paracetamol poisoning. Drug Saf; 7(3): 170-177.

Last update:  January 17, 2009

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