Niacinamide for Anxiety and Depression

Niacin is a nutrient that is used by the body for the generation for the generation of energy and metabolism. Deficiency of niacin results into decreased energy metabolism in the brain. When the body is deficient of Niacin, the tryptophan is converted by the body to Niacinamide which is the amide form of Niacin. Take note that tryptophan is converted by the body to serotonin, the neurotransmitter which makes us feel good. The conversion of tryptophan to niacinamide causes a reduction in the amount of available “feel good” neurotransmitter serotonin. Increasing the dietary intake of Niacin or Niacinamide helps increase serotonin levels in the brain. Niacinamide also goes into the same receptor sites of the brain as with tranquilizers. Thus niacinamide acts like a natural tranquilizer.


The recommended dose for people with depression is 500 mg four times a day. Natural sources of niacinamide includes Beef liver, Brewer’s yeast, Chicken, Halibut, Peanuts, Pork, Salmon, Sunflower seeds, Swordfish, Tuna, Turkey and Veal.



1. The Common Form of Niacin Amide Deficiency Disease, Aniacinamidosis. By author, Bridgeport, CT., 1943
2. Niacinamide therapy for joint mobility. Conn. State Med. J. 17:584-589, 1953
3. Niacinamide, a most neglected vitamin. 1978 Tom Spies Memorial Lecture. Journal Int. Acad. of Preventive Medicine 8:5-25,1983
4. Niacinamide improves mobility in degenerative joint disease. Abstract published in Program of the American Association for the Advancement of Science for its meeting in Philadelphia, May 24-30, 1986

Last update: January 19, 2009

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